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BODIPY FL Verapamil Hydrochloride
| Catalog Number | F01-0219 |
| Category | BODIPY |
| Molecular Formula | C41H56BClF2N4O5 |
| Molecular Weight | 769.18 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
A fluorescent calcium-channel blocker analog for studying drug transport and multidrug resistance. Buy fluorescent dyes online for pharmacological imaging.
Chemical Information
Application
| Synonyms | EverFluor FL Verapamil Hydrochloride |
| Appearance | Solid Powder |
BODIPY FL Verapamil Hydrochloride is a fluorescently labeled version of Verapamil Hydrochloride, a calcium channel blocker commonly used to treat conditions like hypertension, angina, and certain arrhythmias. By incorporating BODIPY FL, a boron-dipyrromethene dye, into the structure of Verapamil, this compound allows for fluorescence-based tracking and analysis. The fluorescent tag enables researchers to monitor the drug's behavior in biological systems, providing valuable insights into its pharmacokinetics, cellular interactions, and mechanisms of action.
One key application of BODIPY FL Verapamil Hydrochloride is in studying cellular uptake and distribution. The fluorescent label allows researchers to track the internalization and movement of Verapamil in live cells. This is particularly useful in understanding how the drug enters and accumulates in specific cell types, such as cardiomyocytes or vascular smooth muscle cells, and how it interacts with cellular compartments. This application provides essential information on the drug's pharmacological effects and therapeutic potential.
Another important application is in investigating drug-receptor binding. BODIPY FL Verapamil Hydrochloride can be used to study its binding interactions with calcium channels, especially the L-type calcium channels that Verapamil targets to exert its therapeutic effects. The fluorescence signal enables precise monitoring of receptor binding kinetics and affinity, helping researchers to understand how Verapamil modulates calcium influx in cardiac and smooth muscle cells, contributing to its therapeutic actions in treating arrhythmias and hypertension.
BODIPY FL Verapamil Hydrochloride is also valuable in pharmacokinetic studies. The fluorescent properties of the compound allow scientists to track its absorption, distribution, metabolism, and excretion (ADME) in animal models. By using fluorescence-based imaging techniques, researchers can monitor the compound's tissue distribution, bioavailability, and elimination patterns. This is essential in optimizing drug formulations and understanding the drug's behavior in the body, which can improve therapeutic outcomes.
Finally, BODIPY FL Verapamil Hydrochloride plays a role in high-throughput screening of potential drug candidates. The fluorescence enables easy detection of drug-receptor interactions in large-scale screening assays, helping researchers identify novel compounds that may modulate calcium channels. This can aid in the discovery of new drugs with similar mechanisms of action, particularly in the treatment of cardiovascular diseases and other disorders related to calcium signaling.
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