BODIPY FL Thapsigargin | CAS 216571-99-2

Catalog Number	F01-0163
Category	BODIPY
Molecular Formula	C44H57BF2N2O12
Molecular Weight	854.74

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Product Introduction

BODIPY FL Thapsigargin is a cell-permeant, green-fluorescent probe used for investigation of thapsigargin binding sites in live cells. Thapsigargin is a potent inhibitor of plasma membrane Ca2+ ATPases and is classified as sesquiterpene lactone. Thapsigargin inhibits the ability of cell to pump calcium into the sarcoplasmic and endoplasmic reticula, resulting in an increase of intracellular calcium concentration.

Chemical Information
Application

Synonyms	EverFluor FL Thapsigargin
Appearance	Solid Powder

BODIPY FL Thapsigargin is a fluorescent probe used in various research applications, particularly in cell biology and biochemistry. Here are some key applications of BODIPY FL Thapsigargin:

Cell Imaging: BODIPY FL Thapsigargin is widely used in live cell imaging to study intracellular calcium signaling. Its fluorescent properties allow researchers to visualize and track calcium dynamics within cells in real time. This is crucial for understanding cellular processes that are dependent on calcium, such as muscle contraction and neurotransmitter release.

Apoptosis Research: Researchers use BODIPY FL Thapsigargin to induce endoplasmic reticulum (ER) stress and initiate apoptosis in cell lines. By tracking the fluorescent signal, scientists can monitor the progression of apoptosis and study the molecular pathways involved. This application is important for understanding the mechanisms of cell death and for developing potential therapeutic interventions in cancer research.

Drug Screening: BODIPY FL Thapsigargin is employed in high-throughput drug screening assays to evaluate the effects of compounds on calcium signaling pathways. By assessing changes in fluorescence, researchers can identify potential drug candidates that modulate calcium homeostasis. This application has significant implications for the development of drugs targeting diseases related to calcium dysregulation, such as heart disease and neurodegenerative disorders.

Biological Research: In addition to its use in cell imaging and apoptosis studies, BODIPY FL Thapsigargin serves as a valuable tool for investigating other aspects of cell biology. Its ability to target the ER and alter calcium concentrations allows for the exploration of ER stress responses and protein folding mechanisms. These studies contribute to a deeper understanding of cellular homeostasis and the intricate network of intracellular signaling pathways.