BODIPY FL Hydrazide

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BODIPY FL Hydrazide

BODIPY FL Hydrazide

Catalog Number F01-0177
Category BODIPY
Molecular Formula C14H17BF2N4O
Molecular Weight 306.12
Catalog Number Size Price Quantity

Product Introduction

BODIPY FL Hydrazide is a green-fluorescent dye that is reactive with aldehyde/ketone on polysaccharides and glycoproteins, yielding a reversible Schiff base product that can be transformed to a stable linkage using a reducing agent like sodium borohydride or sodium cyanoborohydride.

Chemical Information

Synonyms EverFluor FL Hydrazide; 4,4-Difluoro-5,7-Dimethyl-4-Bora-3a,4a-Diaza-s-Indacene-3-Propionic Acid Hydrazide
IUPAC Name 3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)propanehydrazide
Canonical SMILES [B-]1(N2C(=CC(=C2C=C3[N+]1=C(C=C3)CCC(=O)NN)C)C)(F)F
InChI InChI=1S/C14H17BF2N4O/c1-9-7-10(2)20-13(9)8-12-4-3-11(5-6-14(22)19-18)21(12)15(20,16)17/h3-4,7-8H,5-6,18H2,1-2H3,(H,19,22)
InChI Key WFYHYVNCFIXKNN-UHFFFAOYSA-N
Appearance Solid Powder
  • Product Specification
  • Application
Excitation 494
Emission 522

BODIPY FL Hydrazide, a highly fluorescent dye known for its photostability and exceptional fluorescence quantum yield, finds extensive utility in diverse scientific realms. Below are the key applications of BODIPY FL Hydrazide:

Fluorescent Labeling: In scientific pursuits, BODIPY FL Hydrazide emerges as a pivotal tool for labeling various biomolecules like proteins, nucleic acids and carbohydrates. Through conjugation with these biomolecules, researchers gain the ability to monitor their movements in cellular and molecular investigations employing fluorescence microscopy and flow cytometry. This facilitates real-time visualization of biological processes, offering invaluable insights into the dynamic nature of cellular activities and interplays.

Reactive Oxygen Species (ROS) Detection: Within biochemical analyses, BODIPY FL Hydrazide plays a critical role in detecting reactive oxygen species, wherein it interacts with such species to generate a detectable fluorescent signal. This functionality proves indispensable for studying oxidative stress and its implications in diseases such as cancer and neurodegenerative disorders. By quantifying ROS levels, researchers garner a deeper understanding of oxidative stress effects on cellular and tissue health.

Imaging of Biological Tissues: Leveraging its superior photophysical attributes, BODIPY FL Hydrazide emerges as a preferred option for imaging biological tissues in research endeavors. When applied to histological samples, this dye yields high-contrast images that assist in scrutinizing tissue structures and pinpointing specific biomolecules’ locations. This heightened visual clarity, enhanced by BODIPY FL Hydrazide, aids in refining pathological studies and advancing the development of diagnostic instruments, enriching the realm of tissue examinations.

Drug Delivery Research: In the realm of drug delivery systems, BODIPY FL Hydrazide assumes a significant role, enabling the monitoring of therapeutic agent release and distribution mechanisms. By incorporating this dye into liposomes, nanoparticles, or other delivery platforms, researchers can monitor the in vivo distribution of drugs. This innovation proves pivotal in refining drug formulations, ensuring precise targeting and optimizing release profiles, thereby catalyzing advancements in drug delivery strategies.

Computed Properties

Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 3
Exact Mass 306.1463477 g/mol
Monoisotopic Mass 306.1463477 g/mol
Topological Polar Surface Area 63.1Ų
Heavy Atom Count 22
Formal Charge 0
Complexity 602
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes
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