
BODIPY FL Glibenclamide
Catalog Number | F01-0211 |
Category | BODIPY |
Molecular Formula | C37H42BClF2N6O6S |
Molecular Weight | 783.09 |
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Product Introduction
BODIPY FL Glibenclamide is cell-permeant dye that accumulates in the endoplasmic reticulum (ER) of living cells. It has been used for staining ER and also detecting sulfonylurea receptors related to ATP-dependent potassium channels.
Chemical Information |
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Synonyms | ER-Hunt Green; EverFluor FL Glibenclamide |
Appearance | Solid Powder |
- Product Specification
- Application
Excitation | 430 |
Emission | 542 |
BODIPY FL Glibenclamide is a fluorescently labeled derivative of Glibenclamide, a well-known sulfonylurea drug used for managing type 2 diabetes. This compound combines the pharmacological properties of Glibenclamide with the distinctive fluorescence of BODIPY FL, a boron-dipyrromethene dye. The BODIPY FL label allows for the tracking of Glibenclamide's interactions within biological systems, particularly through fluorescence-based detection methods.
One important application of BODIPY FL Glibenclamide is in cellular uptake studies. The fluorescent tag on the compound allows researchers to monitor the internalization and localization of Glibenclamide within cells. By tracking its fluorescence, scientists can observe how the drug is taken up by target cells, particularly pancreatic beta cells, and study its interaction with cellular components. This helps to gain a deeper understanding of the drug's distribution and its mechanisms of action at the cellular level.
Another key application is in drug-receptor binding assays. BODIPY FL Glibenclamide can be used to study the binding of Glibenclamide to its target receptor, the ATP-sensitive potassium (K_ATP) channel in pancreatic cells. The fluorescence signal allows for precise monitoring of the binding kinetics and affinity of Glibenclamide for its receptor, helping researchers to investigate how the drug modulates insulin secretion and glucose homeostasis. This application is essential in understanding the therapeutic effects of Glibenclamide in diabetes treatment.
BODIPY FL Glibenclamide also plays a crucial role in pharmacokinetic studies. The fluorescent nature of the compound allows for the tracking of its absorption, distribution, metabolism, and excretion (ADME) in preclinical models. Researchers can use fluorescence microscopy or flow cytometry to track the drug's movement through tissues and organs, assess its bioavailability, and understand its elimination patterns. This information is important for optimizing drug formulations and determining appropriate dosing regimens.
Lastly, BODIPY FL Glibenclamide can be utilized in high-throughput screening assays to identify new compounds that may interact with the same receptors as Glibenclamide. The fluorescence signal enables efficient detection and quantification of binding interactions, making it a valuable tool for discovering new drugs with similar mechanisms of action, particularly in the context of diabetes and other metabolic disorders.
Applications of Fluorescent Probes & Dyes
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