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Fluorescent Dyes
BODIPY
BODIPY FL C12

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BODIPY FL C12

Catalog Number	F01-0185
Category	BODIPY
Molecular Formula	C23H33BF2N2O2
Molecular Weight	418.33

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Product Introduction

BODIPY FL C12 is a green-fluorescent dye that is reactive with primary amines on biomolecules, and acts as a precursor to fluorescent phospholipids. This fatty-acid derivative may react with amines using a carbodiimide like EDAC or DIPC or may be used to form ester-linked conjugates or acid-halide products. It is relatively insensitive to environment and pH changes.

Chemical Information
Application

Synonyms	EverFluor FL C12; 4,4-Difluoro-5,7-Dimethyl-4-Bora-3a,4a-Diaza-s-Indacene-3-Dodecanoic Acid
Appearance	Solid Powder

BODIPY FL C12 is a fluorescent dye from the BODIPY (boron-dipyrromethene) family, known for its bright green fluorescence and high photostability. The "C12" refers to the 12-carbon chain attached to the BODIPY core structure, which enhances its solubility and makes it suitable for labeling lipophilic molecules or membrane structures. This dye is commonly used in various biological and biochemical applications, particularly in fluorescence microscopy and imaging.

One of the primary applications of BODIPY FL C12 is in lipid membrane labeling. Its hydrophobic tail allows the dye to integrate into cellular membranes, making it an excellent tool for visualizing lipid-rich structures like cell membranes, lipid droplets, and organelles. Researchers use this dye to study membrane dynamics, cellular signaling, and lipid metabolism, which are crucial in understanding processes like endocytosis and membrane trafficking.

BODIPY FL C12 is also widely utilized in cellular uptake studies. By attaching this dye to lipid analogs or compounds of interest, scientists can track the internalization and distribution of these molecules within cells. This application is particularly valuable in drug delivery research, where understanding how lipophilic drugs or nanoparticles are taken up by cells is essential for developing effective therapies.

Another key application of BODIPY FL C12 is in studying lipid metabolism and adipocyte biology. The dye’s ability to label lipid droplets makes it a valuable tool in adipocyte culture systems for studying fat storage, breakdown, and metabolic processes. It is commonly used in obesity research and studies focused on lipid-related disorders such as non-alcoholic fatty liver disease (NAFLD).

Lastly, BODIPY FL C12 plays a role in the development of biosensors for detecting lipid-related biomarkers. The dye's fluorescence properties enable the creation of highly sensitive sensors that can detect changes in lipid composition or concentrations in biological samples. These sensors have applications in clinical diagnostics and environmental monitoring, where accurate lipid measurements are crucial for assessing health and disease states.