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Fluorescent Dyes
BODIPY
β-BODIPY FL C12-HPC

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β-BODIPY FL C12-HPC

Catalog Number	F01-0198
Category	BODIPY
Molecular Formula	C47H81BF2N3O8P
Molecular Weight	895.94

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Product Introduction

β-BODIPY FL C12-HPC is a green-fluorescent lipid membrane probe. It has been used for investigations of lipid uptake, metabolism and storage in living tissues and organisms, and for detection of cell membrane trafficking and lipid domains. This probe is relatively insensitive to environment and pH changes.

Chemical Information
Application

Synonyms	β-EverFluor FL C12-HPC; 2-(4,4-Difluoro-5,7-Dimethyl-4-Bora-3a,4a-Diaza-s-Indacene-3-Dodecanoyl)-1-Hexadecanoyl-sn-Glycero-3-Phosphocholine
Appearance	Solid Powder

β-BODIPY FL C12-HPC is a fluorescent dye that belongs to the BODIPY (boron-dipyrromethene) family. Known for its high fluorescence quantum yield, stability, and minimal photobleaching, it is widely used in research applications requiring precise molecular detection. The "FL" in its name refers to its green fluorescence, while the "C12-HPC" denotes its specific functionalization with a C12 hydrocarbon chain, enhancing its lipophilicity for applications involving lipid-rich environments. Its robust fluorescence properties make it a powerful tool in various biological and chemical applications.

One of the primary applications of β-BODIPY FL C12-HPC is in cellular imaging. Due to its lipophilic nature, it readily integrates into cell membranes, making it ideal for studying membrane dynamics, lipid distribution, and cellular processes involving lipids. Researchers use this dye to track membrane-bound proteins, monitor cell fusion or endocytosis, and observe cellular morphology changes with high resolution and minimal interference.

β-BODIPY FL C12-HPC is also utilized in the development of lipid-based drug delivery systems. It is frequently employed to monitor the behavior of liposomes, micelles, or lipid nanoparticles in drug delivery research. By tagging lipid carriers with the dye, researchers can visualize the delivery, release, and uptake of therapeutic agents in cellular environments. This application is crucial in optimizing drug delivery strategies, particularly for cancer treatment and targeted therapies.

Another key application is in fluorescence resonance energy transfer (FRET) assays. β-BODIPY FL C12-HPC can act as a donor or acceptor in FRET experiments when paired with compatible fluorescent probes. FRET assays are commonly used to study protein-protein interactions, molecular binding events, and conformational changes. Its high fluorescence intensity and photostability make it suitable for dynamic monitoring of molecular interactions in real time.

Lastly, β-BODIPY FL C12-HPC is used in membrane potential assays. Due to its interaction with lipid bilayers, it is effective in monitoring changes in membrane potential in living cells. This is particularly useful in studying ion channel activity, cellular excitability, and drug effects on membrane functions, offering valuable insights in neuroscience, pharmacology, and toxicology research.