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BODIPY
BODIPY 665/676 (Lipid Peroxidation Sensor)

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BODIPY 665/676 (Lipid Peroxidation Sensor)

Catalog Number	F01-0218
Category	BODIPY
Molecular Formula	C29H23BF2N2
Molecular Weight	448.31

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Product Introduction

BODIPY 665/676 (Lipid Peroxidation Sensor) is a lipophilic fluorescent probe that can be used for investigation of radical-driven lipid autoxidation. BODIPY 665/676 is reactive with peroxyl radicals and exhibits a loss in fluorescence emission at the 676 nm wavelength upon reaction with peroxyl radical species.

Chemical Information
Product Specification
Application

Synonyms	EverFluor 665/676 (Lipid Peroxidation Sensor)
Appearance	Solid Powder

Excitation	553
Emission	575

BODIPY 665/676, a fluorescent dye renowned for its utility as a sensor in detecting and quantifying lipid peroxidation in biological systems, finds varied applications. Here are four key applications of BODIPY 665/676:

Oxidative Stress Research: At the forefront of cellular and organismal investigations into oxidative stress, BODIPY 665/676 plays a pivotal role in scrutinizing lipid peroxidation levels. By fluorometrically assessing the generation of reactive oxygen species and ensuing lipid damage, researchers gain insights into the oxidative milieu of cells. This knowledge is paramount in unraveling the intricate nexus between oxidative stress, aging, neurodegeneration, and chronic ailments.

Drug Discovery and Screening: In the domain of pharmaceutical exploration, BODIPY 665/676 serves as a cornerstone for evaluating the efficacy of antioxidant compounds. Through monitoring the abatement of lipid peroxidation, scientists can sift through potential drug candidates that hold promise in mitigating oxidative harm.

Cellular Biochemistry: Facilitating the visualization and quantification of lipid peroxidation within live cells, BODIPY 665/676 empowers researchers with insights gleaned through fluorescence microscopy. By mapping the spatial and temporal distribution of oxidized lipids in cells, scientists uncover pivotal details regarding cellular responses to stressors. This application stands as a cornerstone for elucidating the intricate biochemical pathways underlying cellular lipid turnover and damage.

Environmental Toxicology: In the realm of environmental studies, BODIPY 665/676 emerges as a critical tool for evaluating the impact of environmental toxins on lipid oxidation. Through scrutinizing oxidative damage in biological samples subjected to toxic substances, researchers ascertain the potential risks and mechanisms of toxicity posed by pollutants. This invaluable information aids in conducting environmental risk assessments and formulating strategies for mitigating pollution, thereby safeguarding ecological integrity.