1,2-Dioleoyl-sn-glycero-3-N-carboxyfluoroscein-PE | CAS 384832-91-1

Catalog Number	A16-0061
Category	Lipid Fluorescent Probes
Molecular Formula	C62H88NO14P·2NH3
Molecular Weight	1136.4

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Product Introduction

1,2-Dioleoyl-sn-glycero-3-N-carboxyfluoroscein-PE (DOPE-CF) is a phosphoethanolamine that is tagged with a fluorescent moiety 6-carboxyfluoroscein. It has been used for the study of liposome membrane dynamics in spectrophotometry and FRET.

Chemical Information
Product Specification
Application

Synonyms	1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine N-carboxyfluorescein; 9Z-octadecenoic acid, 1,1'-[(1R)-1-[8-(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)-3-hydroxy-3-oxido-8-oxo-2,4-dioxa-7-aza-3-phosphaoct-1-yl]-1,2-ethanediyl] ester, diammonium salt
Purity	≥98%
Appearance	Solid Powder

Storage

Store at -20°C

1,2-Dioleoyl-sn-glycero-3-N-carboxyfluoroscein-PE (commonly referred to as DOPE-CF) is a lipid derivative where a carboxyfluorescein (CF) fluorescent moiety is covalently attached to the polar head of the phosphatidylethanolamine (PE) molecule. This amphiphilic compound combines the lipid bilayer compatibility of DOPE with the fluorescence properties of CF, making it a valuable tool in various biochemical and biophysical applications.

DOPE-CF is widely used in liposome-based drug delivery systems to track the behavior of lipid carriers. Its fluorescence allows researchers to monitor the distribution and release of encapsulated drugs, enabling optimization of delivery mechanisms.

This compound is crucial in membrane fusion studies. The fluorescence quenching or dequenching of carboxyfluorescein provides a sensitive assay to investigate lipid mixing and fusion events, contributing to the understanding of membrane dynamics.

DOPE-CF also plays a key role in fluorescence imaging and localization studies. Its fluorescent properties make it an ideal marker for visualizing lipid membranes, cell surface dynamics, and intracellular trafficking in live-cell imaging experiments.

In addition, DOPE-CF is utilized in studying lipid-protein interactions. Its integration into lipid bilayers allows researchers to investigate the binding, insertion, or structural effects of proteins on membrane systems, advancing our understanding of cellular processes.