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Rhod-2 potassium salt
| Catalog Number | A14-0035 |
| Category | Calcium, Chloride and Other indicators |
| Molecular Formula | C40H39K3N4O11 |
| Molecular Weight | 869.1 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A14-0035 | -- | -- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Rhod-2 is a red fluorescent calcium indicator. It exhibits a significant shift in fluorescence intensity upon binding to calcium (ex max = 549 nm; calcium-free v. ex/em max = 552/581 nm; calcium-bound).
Chemical Information
Product Specification
Application
| Synonyms | 2,2'-((2-(2-(2-(bis(carboxylatomethyl)amino)-5-(6-(dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl)phenoxy)ethoxy)-4-methylphenyl)azanediyl)diacetate, tripotassium salt |
| Purity | ≥90% |
| Canonical SMILES | CC1=CC(=C(C=C1)N(CC(=O)[O-])CC(=O)[O-])OCCOC2=CC(=C3C4=C(C=C(C=C4)N(C)C)OC5=C3C=CC(=C5)N(C)C)C=CC2=[N+](CC(=O)[O-])CC(=O)[O-].[K+].[K+].[K+] |
| InChI | InChI=1S/C40H42N4O11.3K/c1-24-6-12-30(43(20-36(45)46)21-37(47)48)34(16-24)53-14-15-54-35-17-25(7-13-31(35)44(22-38(49)50)23-39(51)52)40-28-10-8-26(41(2)3)18-32(28)55-33-19-27(42(4)5)9-11-29(33)40;;;/h6-13,16-19H,14-15,20-23H2,1-5H3,(H3-,45,46,47,48,49,50,51,52);;;/q;3*+1/p-3 |
| InChIKey | ZFYWHSXZMYZBNV-UHFFFAOYSA-K |
| Appearance | Solid Powder |
| Excitation | 549 nm (Ca2+-free), 552 nm (Ca2+-bound) |
| Emission | 581 nm (Ca2+-bound) |
| Storage | Store at -20°C |
Rhod-2 potassium salt, a fluorescent calcium indicator, finds diverse applications in biological and medical research arenas. Here are four key applications of Rhod-2 potassium salt:
Live Cell Imaging: Widely utilized in live cell imaging, Rhod-2 potassium salt serves as a pivotal tool for measuring intracellular calcium levels. Its fluorescence upon binding to calcium enables real-time visualization of calcium signaling dynamics within cells. Researchers can monitor calcium fluctuations to delve into cellular processes like muscle contraction, neurotransmission, and apoptosis in a dynamic and detailed manner.
Cardiac Research: In the realm of cardiac research, Rhod-2 potassium salt plays a crucial role in investigating calcium transients in heart cells. Loading cardiomyocytes with this indicator allows researchers to explore the intricate mechanisms of excitation-contraction coupling and calcium-induced calcium release with precision and depth. This application is fundamental for unraveling the complexities of heart function and for evaluating potential cardiac-affecting drugs through a lens of high-resolution understanding.
Neuroscience: Extensively utilized in neuroscience, Rhod-2 potassium salt facilitates the analysis of calcium signaling in neurons. Neurobiologists leverage this indicator to track calcium dynamics in response to stimuli or synaptic activity, shedding light on the intricacies of neuronal communication and the underlying mechanisms of neurological disorders. This tool empowers researchers to delve into the rich tapestry of neural signaling with exceptional granularity and depth.
Pharmacology Screening: In the domain of pharmacological screening, Rhod-2 potassium salt serves as a valuable asset for assessing the effects of drugs on cellular calcium levels. High-throughput assays designed with this indicator enable the measurement of compound impacts on calcium signaling pathways in varied cell types. This approach streamlines the discovery and characterization of novel therapeutic agents that modulate calcium homeostasis, offering a nuanced understanding of drug effects on cellular calcium dynamics.
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