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Phalloidin-FITC | CAS 915026-99-2
| Catalog Number | A16-0004 |
| Category | Cytoskeleton Fluorescent Probes |
| Molecular Formula | C56H60N10O15S2 |
| Molecular Weight | 1177.26 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A16-0004 | -- | -- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Phalloidin-FITC is fluorophore-labeled phalloidin used for visualizing the actin cytoskeleton.
Chemical Information
Product Specification
Application
| Synonyms | FITC-bicyclic(Ala-DThr-Cys-cis-4-hydroxy-Pro-Ala-2-mercapto-Trp-5-amino-4-hydroxy-Leu)(S-3→6); Cyclo(-Ala-D-Thr-Cys-cis-Hyp-Ala-Trp-(4R)-4-hydroxy-4-Me-Orn(FITC)) (Sulfide bond between Cys and indol-2-yl); 7-[(4R)-N5-[[(3',6'-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)amino]thioxomethyl]-4-hydroxy-4-methyl-L-ornithine]phalloidin; ((R)-4-Hydroxy-4-methyl-Orn(FITC)7)-Phalloidin |
| Purity | ≥90% |
| IUPAC Name | 5-[[(2R)-2-hydroxy-3-[(1S,14S,18R,20S,23S,28S,34R)-18-hydroxy-34-[(1S)-1-hydroxyethyl]-23,31-dimethyl-15,21,24,26,29,32,35-heptaoxo-12-thia-10,16,22,25,27,30,33,36-octazapentacyclo[12.11.11.03,11.04,9.016,20]hexatriaconta-3(11),4,6,8-tetraen-28-yl]-2-methylpropyl]carbamothioylamino]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid |
| Canonical SMILES | CC1C(=O)NC2CC3=C(NC4=CC=CC=C34)SCC(C(=O)N5CC(CC5C(=O)N1)O)NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CC(C)(CNC(=S)NC6=CC(=C(C=C6)C7=C8C=CC(=O)C=C8OC9=C7C=CC(=C9)O)C(=O)O)O)C)C(C)O |
| InChI | InChI=1S/C56H60N10O15S2/c1-24-46(71)61-38-19-35-31-7-5-6-8-37(31)64-52(35)83-22-40(53(77)66-21-30(70)16-41(66)50(75)59-24)63-51(76)45(26(3)67)65-47(72)25(2)58-49(74)39(62-48(38)73)20-56(4,80)23-57-55(82)60-27-9-12-32(36(15-27)54(78)79)44-33-13-10-28(68)17-42(33)81-43-18-29(69)11-14-34(43)44/h5-15,17-18,24-26,30,38-41,45,64,67-68,70,80H,16,19-23H2,1-4H3,(H,58,74)(H,59,75)(H,61,71)(H,62,73)(H,63,76)(H,65,72)(H,78,79)(H2,57,60,82)/t24-,25?,26-,30+,38-,39-,40+,41-,45+,56+/m0/s1 |
| InChIKey | WUSBHBKXQMYBEH-UVSDEEQGSA-N |
| Solubility | Soluble in Water |
| Density | 1.6±0.1 g/cm3 |
| Appearance | Yellow Lyophilized Powder |
| Storage | Store at -20°C |
Phalloidin-FITC, a fluorescently labeled compound, is a versatile tool widely employed in the exploration of actin filaments within cellular contexts. Here are four key applications of Phalloidin-FITC:
Actin Filament Staining: With its specific affinity for actin filaments, Phalloidin-FITC enables researchers to visualize and scrutinize the cytoskeletal architecture in fixed cells using fluorescence microscopy. This precise staining technique plays a pivotal role in unraveling cellular processes such as motility, division, and structural organization. Researchers can capture detailed images, unveiling the intricate web of the actin cytoskeleton, shedding light on its dynamic nature.
Cell Morphology Analysis: By selectively staining actin filaments with Phalloidin-FITC, scientists can delve into changes in cell shape, structure, and dynamics in response to various stimuli or environmental conditions. This analytical approach is essential for investigating phenomena like cell migration, adhesion, and signal transduction. The fluorescent labeling offers a high-resolution glimpse into cellular morphology, facilitating detailed observations of cellular changes.
Drug Screening: In the realm of drug discovery, Phalloidin-FITC serves as a valuable tool for assessing the impact of novel compounds on the actin cytoskeleton. By monitoring changes in fluorescence patterns, researchers can pinpoint compounds that disrupt or stabilize actin filaments, aiding in the identification of potential therapeutics targeting actin dynamics in diseases such as cancer. This screening method provides insights into the effects of compounds on cellular structures at a microscopic level.
Cellular Imaging: In the realm of multicolor fluorescence imaging, Phalloidin-FITC plays a crucial role alongside other fluorescent markers in exploring the co-localization and interactions of actin filaments with diverse cellular structures. This multidimensional visualization strategy offers comprehensive insights into cellular architecture and function, enabling researchers to establish correlations between actin dynamics and other intracellular processes. The integration of multiple fluorescence markers enhances the depth of understanding of cellular interactions and dynamics.
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