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The endoplasmic reticulum fluorescent probes can not only visualize the endoplasmic reticulum, but also further detect its active substances, microenvironment and physiological processes, which have important guiding value for the diagnosis and treatment of diseases. At present, endoplasmic reticulum targeted fluorescent probes include simple endoplasmic reticulum imaging, metal ions, small molecular substances, large molecular substances, microenvironment and so on.
Characteristics of Endoplasmic Reticulum Fluorescent Probes
Endoplasmic reticulum fluorescent probes have specific endoplasmic reticulum targeting, identifies and provides target information in endoplasmic reticulum. Endoplasmic reticulum fluorescent probes usually modify specific reactive groups and endoplasmic reticulum localization groups on the structure of common fluorescent groups such as naphthalimide, fluoroboron pyrrole and rhodamine. Ensure that the probes have high quantum yield, larger stokes displacement and better optical stability.
Applications of Endoplasmic Reticulum Fluorescent Probes
Endoplasmic reticulum fluorescence probes are mainly used for fluorescence imaging of endoplasmic reticulum and active small molecules in endoplasmic reticulum.
- Used to realize endoplasmic reticulum fluorescence imaging
The endoplasmic reticulum fluorescent probes can make the endoplasmic reticulum fluorescently imaged, and then it can track the changes of endoplasmic reticulum position and morphology in real time and observe its physiological process.
- Used to detect metalions in the endoplasmic reticulum
Ionic endoplasmic reticulum fluorescent probes are used for recognition and imaging of metal ions in the endoplasmic reticulum, such as Ca2+, Cu2+, Zn2+, Fe3+ and so on. Therefore, the main role of these ions in human physiological and pathological changes can be accurately found through the specific labeling of fluorescent probes.
- Used to detect small molecules in the endoplasmic reticulum
Small molecular substance endoplasmic reticulum fluorescent probes are mainly used to detect small molecular substances in cellular endoplasmic reticulum, such as reactive oxygen species, hypochlorite, HNO, H2S, formaldehyde, etc. This is of great significance for fluorescence recognition of small molecules. Some fluorescence probes with good performance have been developed to monitor the changes of small and medium molecular substances in tissues.
- Used to detect macromolecular substances in the endoplasmic reticulum
This type of probes can effectively monitor the changes of macromolecular substances in tissues, such as carboxyesterase, caspase, aminopeptidase, etc., and can fully understand the endoplasmic reticulum environment to evaluate the occurrence and development of diseases and provide support for targeted disease treatment.
- Used to detect microenvironment in the endoplasmic reticulum
This kind of probes can monitor the changes of tumor microenvironment in real time, and are particularly sensitive to pH, temperature, viscosity and membrane fluidity in the environment, so they can find metabolic diseases induced by abnormal cells as early as possible.