7-Amino-4-chloromethylcoumarin

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7-Amino-4-chloromethylcoumarin

7-Amino-4-chloromethylcoumarin | CAS 147963-22-2

Catalog Number A16-0077
Category Cell Proliferation Tracer Fluorescent Probes
Molecular Formula C10H8NO2Cl
Molecular Weight 209.63
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Product Introduction

7-Amino-4-chloromethylcoumarin is a thiol-reactive, cell-permeant, fluorescent probe that is commonly used as a long-term cell tracer. It is well retained in cells for at least 24 hours.

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Synonyms CellHunt Blue CMAC; 7-amino-4-(chloromethyl)-2H-chromen-2-one; 7-amino-4-(chloromethyl)chromen-2-one
IUPAC Name 7-amino-4-(chloromethyl)chromen-2-one
Canonical SMILES C1=CC2=C(C=C1N)OC(=O)C=C2CCl
InChI InChI=1S/C10H8ClNO2/c11-5-6-3-10(13)14-9-4-7(12)1-2-8(6)9/h1-4H,5,12H2
InChIKey VIEYMVWPECAOCY-UHFFFAOYSA-N
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 1
Exact Mass 209.0243562 g/mol
Monoisotopic Mass 209.0243562 g/mol
Topological Polar Surface Area 52.3Ų
Heavy Atom Count 14
Formal Charge 0
Complexity 277
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes
PMID Publication Date Title Journal
20162389 2011-01-01 Wallerian-like degeneration of central neurons after synchronized and geometrically registered mass axotomy in a three-compartmental microfluidic chip Neurotoxicity research
21765948 2011-01-01 Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats PloS one
21184674 2010-12-24 Tetherin restricts direct cell-to-cell infection of HIV-1 Retrovirology
21049044 2010-10-25 Moderation of calpain activity promotes neovascular integration and lumen formation during VEGF-induced pathological angiogenesis PloS one
19114102 2009-04-01 Spitzenkörper, vacuoles, ring-like structures, and mitochondria of Phanerochaete velutina hyphal tips visualized with carboxy-DFFDA, CMAC and DiOC6(3) Mycological research
Publication Number Title Priority Date
WO-2022240655-A1 Methods of using shaped particles in flow cytometers for assays on b cells and t cells 2021-05-10
EP-4071148-A1 Dichalcogenide prodrugs 2021-04-07
WO-2022214598-A1 Dichalcogenide prodrugs 2021-04-07
EP-4062942-A1 Disulfide-based prodrug compounds 2021-03-22
WO-2022200347-A1 Disulfide-based prodrug compounds 2021-03-22

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