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TCO-PEG3-amide-C3-triethoxysilane | CAS 2250217-32-2
| Catalog Number | R15-0005 |
| Category | Trans Cyclooctene (TCO) |
| Molecular Formula | C₂₇H₅₂N₂O₉Si |
| Molecular Weight | 576.80 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R15-0005 | -- | -- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
TCO-PEG3-amide-C3-triethoxysilane is a polyethylene glycol (PEG)-based PROTAC linker. TCO-PEG3-amide-C3-triethoxysilane can be used in the synthesis of a series of PROTACs.
Chemical Information
Product Specification
Application
Computed Properties
| Synonyms | TCO-PEG3-triethoxysilane |
| Purity | 95% |
| IUPAC Name | [(4Z)-cyclooct-4-en-1-yl] N-[2-[2-[2-[3-oxo-3-(3-triethoxysilylpropylamino)propoxy]ethoxy]ethoxy]ethyl]carbamate |
| Canonical SMILES | CCO[Si](CCCNC(=O)CCOCCOCCOCCNC(=O)OC1CCCC=CCC1)(OCC)OCC |
| InChI | InChI=1S/C27H52N2O9Si/c1-4-35-39(36-5-2,37-6-3)24-12-16-28-26(30)15-18-32-20-22-34-23-21-33-19-17-29-27(31)38-25-13-10-8-7-9-11-14-25/h7-8,25H,4-6,9-24H2,1-3H3,(H,28,30)(H,29,31)/b8-7- |
| InChIKey | ZXQAFZQBZKLJGI-FPLPWBNLSA-N |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
TCO-PEG3-amide-C3-triethoxysilane, a versatile chemical reagent with profound implications in materials science and biotechnology, finds diverse applications. Here are four key applications:
Surface Functionalization: In materials modification, TCO-PEG3-amide-C3-triethoxysilane plays a crucial role in altering the properties of glass and silica-based surfaces to imbue them with bio-friendly attributes. By applying this reagent, surfaces gain hydrophilicity and biocompatibility, making them suitable for biosensors and diagnostic utilities. This transformative process is pivotal for enhancing the efficacy and durability of bioanalytical tools significantly.
Bioconjugation: Serving as a pivotal linker in bioconjugation methodologies, this compound facilitates the binding of biomolecules to surfaces, with the PEG3 spacer offering a blend of flexibility and stability. Through adept attachment of proteins, peptides, or other biomolecules to surfaces, their seamless interaction in bioassays is promoted, enhancing the sensitivity and specificity of diagnostic and therapeutic platforms across diverse applications.
Nanoparticle Stabilization: Critical for nanoparticle stabilization, TCO-PEG3-amide-C3-triethoxysilane ensures the safeguarding of nanoparticles by enveloping them in a protective PEG layer on their surface. This protective shield is indispensable for maintaining colloidal stability and biocompatibility of nanoparticles in physiological milieus, thereby preventing aggregation and enhancing targeted delivery and controlled release of therapeutic agents in the realm of nanomedicine.
Click Chemistry: In the realm of chemical biology, this reagent emerges as a valuable resource for click chemistry endeavors, specifically in the domain of strain-promoted alkyne-azide cycloaddition (SPAAC). The TCO group exhibits efficient reactivity with azides, enabling precise labeling and conjugation of biomolecules at specific sites. This application finds widespread use in imaging, drug delivery, and innovative development of biomaterials for research and therapeutic applications, marking a significant advancement in these domains.
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 24 |
| Exact Mass | 576.34420777 g/mol |
| Monoisotopic Mass | 576.34420777 g/mol |
| Topological Polar Surface Area | 123Ų |
| Heavy Atom Count | 39 |
| Formal Charge | 0 |
| Complexity | 638 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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