3,3'-Dipropyloxacarbocyanine iodide | 53213-79-9

Catalog Number	A16-0163
Category	Cell membrane Fluorescent Probes
Molecular Formula	C23H25IN2O2
Molecular Weight	488.36

Catalog Number	Size	Price	Quantity
A16-0163	--	$--

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Product Introduction

3,3'-Dipropyloxacarbocyanine iodide is a lipophilic fluorescent stain for labeling membranes.

Chemical Information
Product Specification
Application

Synonyms	DiOC3(3)
IUPAC Name	(2Z)-3-propyl-2-[(E)-3-(3-propyl-1,3-benzoxazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzoxazole;iodide
Canonical SMILES	CCCN1C2=CC=CC=C2OC1=CC=CC3=[N+](C4=CC=CC=C4O3)CCC.[I-]
InChI	InChI=1S/C23H25N2O2.HI/c1-3-16-24-18-10-5-7-12-20(18)26-22(24)14-9-15-23-25(17-4-2)19-11-6-8-13-21(19)27-23;/h5-15H,3-4,16-17H2,1-2H3;1H/q+1;/p-1
InChI Key	LWWWYHFXRJVZBL-UHFFFAOYSA-M

Excitation	490
Emission	510
Signal	Warning
GHS Hazard Statements	H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

3,3’-Dipropyloxacarbocyanine iodide, also known as DiOC6(3), is a fluorescent dye with significant applications in biomedical research. Here are four key applications of this dye:

Mitochondrial Membrane Potential Measurement: Widely utilized for assessing mitochondrial membrane potential in live cells, DiOC6(3) plays a critical role in evaluating the vitality and functionality of mitochondria through fluorescence intensity analysis. This data is pivotal for exploring cellular bioenergetics and unraveling the intricacies of diseases associated with mitochondrial abnormalities.

Cell Viability Assays: In the realm of cell viability assessments, DiOC6(3) stands out as a versatile tool when combined with other dyes to gauge cell survival rates. By contrasting fluorescence signals from live and deceased cells, researchers can quantitatively analyze cell viability under diverse experimental conditions, particularly beneficial for drug screening endeavors and toxicity investigations.

Cellular Membrane Studies: Embodying lipophilic characteristics, DiOC6(3) serves as a valuable dye for labeling various cellular membranes, facilitating the visualization of cellular structures via fluorescence microscopy. This capability empowers scientists to delve into membrane dynamics, organization, and compartmentalization within cells, offering profound insights into intracellular trafficking mechanisms and membrane-related processes.

Flow Cytometry: Integrating seamlessly into flow cytometry analyses, DiOC6(3) plays a pivotal role in scrutinizing membrane potential fluctuations across a large cell population. Through quantifying fluorescence intensity variations, researchers gain a comprehensive understanding of mitochondrial function heterogeneity within cell samples, an indispensable tool for investigating apoptosis and cellular stress responses comprehensively.

Computed Properties
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	488.09608 g/mol
Monoisotopic Mass	488.09608 g/mol
Topological Polar Surface Area	29.5Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	500
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

Patents

Publication Number	Title	Priority Date
WO-2019206298-A1	Reagent, method for analyzing platelets and blood cell analyzer	2018-04-28
CN-111656188-B	Reagent, method for analyzing platelet and blood cell analyzer	2018-04-28
WO-2019069853-A1	RADIATION DOSIMETRY SOL OR GEL AND RADIATION DOSIMETER WITH SUCH FLOOR OR GEL AS RADIATION DOSIMETRY MATERIAL	2017-10-02
EP-3686632-A1	Radiation dosimetry sol or gel and radiation dosimeter comprising same as material for radiation dosimetry	2017-10-02
US-2020333474-A1	Radiation dosimetry sol or gel and radiation dosimeter comprising same as material for radiation dosimetry	2017-10-02