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3,3'-Dipropyloxacarbocyanine iodide | 53213-79-9
| Catalog Number | A16-0163 |
| Category | Cell membrane Fluorescent Probes |
| Molecular Formula | C23H25IN2O2 |
| Molecular Weight | 488.36 |
| Catalog Number | Size | Price | Quantity |
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* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
3,3'-Dipropyloxacarbocyanine iodide is a lipophilic fluorescent stain for labeling membranes.
Chemical Information |
|
|---|---|
| Synonyms | DiOC3(3) |
| IUPAC Name | (2Z)-3-propyl-2-[(E)-3-(3-propyl-1,3-benzoxazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzoxazole;iodide |
| Canonical SMILES | CCCN1C2=CC=CC=C2OC1=CC=CC3=[N+](C4=CC=CC=C4O3)CCC.[I-] |
| InChI | InChI=1S/C23H25N2O2.HI/c1-3-16-24-18-10-5-7-12-20(18)26-22(24)14-9-15-23-25(17-4-2)19-11-6-8-13-21(19)27-23;/h5-15H,3-4,16-17H2,1-2H3;1H/q+1;/p-1 |
| InChI Key | LWWWYHFXRJVZBL-UHFFFAOYSA-M |
- Product Specification
- Application
| Excitation | 490 |
| Emission | 510 |
| Signal | Warning |
| GHS Hazard Statements | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
3,3’-Dipropyloxacarbocyanine iodide, also known as DiOC6(3), is a fluorescent dye with significant applications in biomedical research. Here are four key applications of this dye:
Mitochondrial Membrane Potential Measurement: Widely utilized for assessing mitochondrial membrane potential in live cells, DiOC6(3) plays a critical role in evaluating the vitality and functionality of mitochondria through fluorescence intensity analysis. This data is pivotal for exploring cellular bioenergetics and unraveling the intricacies of diseases associated with mitochondrial abnormalities.
Cell Viability Assays: In the realm of cell viability assessments, DiOC6(3) stands out as a versatile tool when combined with other dyes to gauge cell survival rates. By contrasting fluorescence signals from live and deceased cells, researchers can quantitatively analyze cell viability under diverse experimental conditions, particularly beneficial for drug screening endeavors and toxicity investigations.
Cellular Membrane Studies: Embodying lipophilic characteristics, DiOC6(3) serves as a valuable dye for labeling various cellular membranes, facilitating the visualization of cellular structures via fluorescence microscopy. This capability empowers scientists to delve into membrane dynamics, organization, and compartmentalization within cells, offering profound insights into intracellular trafficking mechanisms and membrane-related processes.
Flow Cytometry: Integrating seamlessly into flow cytometry analyses, DiOC6(3) plays a pivotal role in scrutinizing membrane potential fluctuations across a large cell population. Through quantifying fluorescence intensity variations, researchers gain a comprehensive understanding of mitochondrial function heterogeneity within cell samples, an indispensable tool for investigating apoptosis and cellular stress responses comprehensively.
Computed Properties | |
|---|---|
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 6 |
| Exact Mass | 488.09608 g/mol |
| Monoisotopic Mass | 488.09608 g/mol |
| Topological Polar Surface Area | 29.5Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 500 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 2 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2019206298-A1 | Reagent, method for analyzing platelets and blood cell analyzer | 2018-04-28 |
| CN-111656188-B | Reagent, method for analyzing platelet and blood cell analyzer | 2018-04-28 |
| WO-2019069853-A1 | RADIATION DOSIMETRY SOL OR GEL AND RADIATION DOSIMETER WITH SUCH FLOOR OR GEL AS RADIATION DOSIMETRY MATERIAL | 2017-10-02 |
| EP-3686632-A1 | Radiation dosimetry sol or gel and radiation dosimeter comprising same as material for radiation dosimetry | 2017-10-02 |
| US-2020333474-A1 | Radiation dosimetry sol or gel and radiation dosimeter comprising same as material for radiation dosimetry | 2017-10-02 |
