Amino-11-dUTP

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Amino-11-dUTP

Amino-11-dUTP

Catalog Number R11-0002
Category DNA Stains
Molecular Formula C18H62Li3N4O33P3
Molecular Weight 976.44
Catalog Number Size Price Quantity
R11-0002 -- $--

Product Introduction

Amino-11-dUTP is an improved replacement for Aminoallyl dUTP. This triphosphate features longer linker, which allows for easier and more facile downstream labeling.Amino-11-dUTP is compatible with PCR, nick translation, and reverse transcription. It can be used for microarray labeling. The nucleotide is incorporated by Taq DNA polymerase, Klenow fragment, and reverse transcriptases. Subsequent reaction of amino-DNA with activated esters can be used for the labeling of DNA.

Chemical Information

Purity NMR 1H and 31P, HPLC (99+%), PCR testing
IUPAC Name [[[(2R,3R,5R)-5-[5-[3-(4-aminobutanoylamino)prop-1-ynyl]-2,4-dioxopyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate
Canonical SMILES C1C(C(OC1N2C=C(C(=O)NC2=O)C#CCNC(=O)CCCN)COP(=O)([O-])OP(=O)([O-])OP(=O)(O)[O-])O
InChI InChI=1S/C16H25N4O15P3/c17-5-1-4-13(22)18-6-2-3-10-8-20(16(24)19-15(10)23)14-7-11(21)12(33-14)9-32-37(28,29)35-38(30,31)34-36(25,26)27/h8,11-12,14,21H,1,4-7,9,17H2,(H,18,22)(H,28,29)(H,30,31)(H,19,23,24)(H2,25,26,27)/p-3/t11-,12-,14-/m1/s1
InChI Key LALQWMWAKIGPOJ-YRGRVCCFSA-K
Solubility good in water
Appearance colorless solid
  • Product Specification
Storage 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

Computed Properties

XLogP3 -8.8
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 16
Rotatable Bond Count 13
Exact Mass 603.02945200 g/mol
Monoisotopic Mass 603.02945200 g/mol
Topological Polar Surface Area 302Ų
Heavy Atom Count 38
Formal Charge -3
Complexity 1150
Isotope Atom Count 0
Defined Atom Stereocenter Count 3
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Patents

Publication NumberTitlePriority Date
JP-6711352-B2 Probe reagents for in situ hybridization 2015-05-28
JP-WO2016190236-A1 Probe reagents for in situ hybridization 2015-05-28
WO-2016190236-A1 Probe reagent for in-situ hybridization 2015-05-28
EP-3121291-A1 Probe reagent and fish using probe reagent 2014-03-20
JP-2020089367-A Probe reagent and FISH using the probe reagent 2014-03-20
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