6-Fluorescein phosphoramidite | 204697-37-0

Catalog Number	R10-0005
Category	Phosphoramidite
Molecular Formula	C46H58N3O10P
Molecular Weight	843.94

Catalog Number	Size	Price	Quantity
R10-0005	--	$--

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Product Introduction

6-Fluorescein phosphoramidite is prepared from 6-carboxyfluorescein derivatives and does not contain 4,4'-dimethoxytrityl (DMT) groups. It can only be added once at the 5'end to terminate the synthesis.

Chemical Information
Synonyms	FAM Phosphoramidite, 6-Isomer; 6-FAM phosphoramidite; FAM phosphoramidite, 6-isomer; DyLight FAM-6 CEP; 5'(6)-FAM; 5'-6-Fluorescein phosphoramidite; 6-((6-(((2-Cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl)carbamoyl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)
Purity	≥90%
IUPAC Name	[6-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate
Canonical SMILES	CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC2=C(C=C1)C(=O)OC23C4=C(C=C(C=C4)OC(=O)C(C)(C)C)OC5=C3C=CC(=C5)OC(=O)C(C)(C)C)OCCC#N
InChI	InChI=1S/C46H58N3O10P/c1-29(2)49(30(3)4)60(55-25-15-22-47)54-24-14-12-11-13-23-48-40(50)31-16-19-34-37(26-31)46(59-41(34)51)35-20-17-32(56-42(52)44(5,6)7)27-38(35)58-39-28-33(18-21-36(39)46)57-43(53)45(8,9)10/h16-21,26-30H,11-15,23-25H2,1-10H3,(H,48,50)
InChI Key	MGPYJVWEJNTXLC-UHFFFAOYSA-N
Solubility	Soluble in Acetonitrile, DCM
Appearance	White to Off-white Solid
Boiling Point	850.6±65.0°C at 760 mmHg

Product Specification

ε, L⋅mol-1⋅cm-1	75000
Fluorescence Quantum Yield	0.9
Excitation	494
Emission	520
Storage	Store at -20 °C

Computed Properties
XLogP3	8.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	21
Exact Mass	843.38598205 g/mol
Monoisotopic Mass	843.38598205 g/mol
Topological Polar Surface Area	163Å²
Heavy Atom Count	60
Formal Charge	0
Complexity	1470
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Patents

Publication Number	Title	Priority Date
US-2020256857-A1	Universal histidine-tag binding compounds and methods of use thereof as fluorescent probes and sensors	2014-04-29
WO-2014120681-A2	Optical element for correcting color blindness	2013-01-29
EP-2739997-B1	Optical element for correcting color blindness	2011-08-05
US-2013032758-A1	Optical Element for Correcting Color Blindness	2011-08-05
US-2013033776-A1	Optical Element for Correcting Color Blindness	2011-08-05

Applications of Fluorescent Probes & Dyes

Laser Dye

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6-Fluorescein phosphoramidite | 204697-37-0

Product Introduction

Chemical Information

Computed Properties

Patents