Thioflavin T

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Thioflavin T

Thioflavin T | 2390-54-7

Catalog Number A01-0008
Category Fluorescent Proteins, Nucleotides & Other Conjugates
Molecular Formula C17H19ClN2S
Molecular Weight 318.86
Catalog Number Size Price Quantity
A01-0008 -- $--

Product Introduction

A cell-permeable cationic benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid in tissue sections.

Chemical Information

Synonyms Basic Yellow 1;2-(p-(dimethylamino)phenyl)-3,6-dimethylbenzothiazolium chloride; thioflavin S; thioflavine; ThT (dye)
Purity >95.0%(HPLC)
IUPAC Name 4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline;chloride
Canonical SMILES CC1=CC2=C(C=C1)[N+](=C(S2)C3=CC=C(C=C3)N(C)C)C.[Cl-]
InChI InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
InChI Key JADVWWSKYZXRGX-UHFFFAOYSA-M
Solubility H2O: ≥ 30 mg/mL
Appearance Yellow to ochre-yellow powder
Melting Point 212°C
MDL Number MFCD00011944
  • Product Specification
Maximum Absorption Wavelength 412(H2O) nm
Storage Store in a cool and dry place (or refer to the Certificate of Analysis).
Signal Danger
GHS Hazard Statements H301 (83.33%): Toxic if swallowed [Danger Acute toxicity, oral] H317 (66.67%): May cause an allergic skin reaction [Warning Sensitization, Skin] H318 (66.67%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H319 (16.67%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H400 (66.67%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (66.67%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] H411 (16.67%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
Precautionary Statement Codes P261, P264, P264+P265, P270, P272, P273, P280, P301+P316, P302+P352, P305+P351+P338, P305+P354+P338, P317, P321, P330, P333+P313, P337+P317, P362+P364, P391, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Computed Properties

Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 2
Exact Mass 318.0957475 g/mol
Monoisotopic Mass 318.0957475 g/mol
Topological Polar Surface Area 35.4Ų
Heavy Atom Count 21
Formal Charge 0
Complexity 325
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
Compound Is Canonicalized Yes

Literatures

PMIDPublication DateTitleJournal
27297626 2016-11-25 Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence Chemico-biological interactions
23528352 2013-05-05 Inhibition of human islet amyloid polypeptide or amylin aggregation by two manganese-salen derivatives European journal of pharmacology
22766284 2012-12-01 Surface chemistry at the nanometer scale influences insulin aggregation Colloids and surfaces. B, Biointerfaces
22955637 2012-11-07 Unzipping the role of chirality in nanoscale self-assembly of tripeptide hydrogels Nanoscale
23067245 2012-11-05 Influence of the valine zipper region on the structure and aggregation of the basic leucine zipper (bZIP) domain of activating transcription factor 5 (ATF5) Molecular pharmaceutics

Patents

Publication NumberTitlePriority Date
CN-115232195-A Oligopeptide two-dimensional nanomaterials and their applications 2022-07-25
CN-115025204-A A compound of dipeptide compounds that inhibits Aβ42 aggregation and reduces its cytotoxicity 2022-07-20
CN-115197689-A A kind of functionalized upconversion nanoparticle of photo-oxidative protein and its preparation method and application 2022-07-06
CN-115201302-A Electrochemical sensor, preparation method and application thereof 2022-07-04
CN-115141265-A Quaternary allosteric pyruvate isoenzyme M2-type activating peptide and its application in reversing the Warburg effect and tumor chemotherapy 2022-06-30
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