Methyltetrazine-PEG4-amine

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Methyltetrazine-PEG4-amine

Methyltetrazine-PEG4-amine | 1802908-05-9

Catalog Number R08-0042
Category Tetrazines
Molecular Formula C₁₇H₂₅N₅O₄
Molecular Weight 363.41
Catalog Number Size Price Quantity
R08-0042 -- $--

Product Introduction

Methyltetrazine-PEG4-amine is a polyethylene glycol (PEG)-based PROTAC linker. Methyltetrazine-PEG4-amine can be used in the synthesis of a series of PROTACs.

Chemical Information

Synonyms Methyltetrazine-PEG4-amine HCl salt
Purity 95%
IUPAC Name 2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethanamine
Canonical SMILES CC1=NN=C(N=N1)C2=CC=C(C=C2)OCCOCCOCCOCCN
InChI InChI=1S/C17H25N5O4/c1-14-19-21-17(22-20-14)15-2-4-16(5-3-15)26-13-12-25-11-10-24-9-8-23-7-6-18/h2-5H,6-13,18H2,1H3
InChI Key JOEAATMYJGXMGS-UHFFFAOYSA-N
Solubility Water, DMSO, DMF, DCM
  • Product Specification
Storage Please store the product under the recommended conditions in the Certificate of Analysis.

Computed Properties

XLogP3 -0.7
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 13
Exact Mass 363.19065430 g/mol
Monoisotopic Mass 363.19065430 g/mol
Topological Polar Surface Area 115Ų
Heavy Atom Count 26
Formal Charge 0
Complexity 337
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Patents

Publication NumberTitlePriority Date
WO-2022094148-A1 Conjugation reagents and methods using 1,2-cyclohexanediones 2020-10-30
WO-2022026915-A9 Anti-tm4sf1 antibody-drug conjugates comprising cleavable linkers and methods of using same 2020-07-31
EP-3919091-A1 Bioink for reversibly forming a hydrogel by light 2020-06-05
US-2021325398-A1 Targeted sialic acid labeling compounds, methods, and uses thereof 2020-04-15
JP-2021523896-A Injectable composition for use as a filler or drug transmitter through a click chemistry reaction 2019-02-27
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