Spacer C18 CE Phosphoramidite

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Spacer C18 CE Phosphoramidite

Spacer C18 CE Phosphoramidite | 125607-09-2

Catalog Number R10-0006
Category Phosphoramidite
Molecular Formula C42H61N2O10P
Molecular Weight 784.91
Catalog Number Size Price Quantity
R10-0006 -- $--

Product Introduction

Hexaethylene glycol phosphoramidite is used to insert a spacer arm in an oligonucleotide and may be added in multiple additions when a longer spacer is required.

Chemical Information

Synonyms Spacer 18 Amidite; Hexaethylene glycol phosphoramidite; 18-O-(4,4'-Dimethoxytrityl)-hexaethylene glycol-1-[[(2-cyanoethyl)-(N,N-diisopropyl)]-Phosphoramidite; 1,1-bis(4-methoxyphenyl)-1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-yl (2-cyanoethyl) diisopropylphosphoramidite; Spacer 18 Phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 19,19-bis(4-methoxyphenyl)-19-phenyl-3,6,9,12,15,18-hexaoxanonadec-1-yl 2-cyanoethyl ester; 19,19-Bis(4-methoxyphenyl)-19-phenyl-3,6,9,12,15,18-hexaoxanonadec-1-yl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Spacer Phosphoramidite 18; DMT Hexaethylene Glycol phosphoramidite
Purity ≥95.0%
IUPAC Name 3-[2-[2-[2-[2-[2-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
Canonical SMILES CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCOCCOCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC
InChI InChI=1S/C42H61N2O10P/c1-35(2)44(36(3)4)55(53-22-10-21-43)54-34-32-51-30-28-49-26-24-47-23-25-48-27-29-50-31-33-52-42(37-11-8-7-9-12-37,38-13-17-40(45-5)18-14-38)39-15-19-41(46-6)20-16-39/h7-9,11-20,35-36H,10,22-34H2,1-6H3
InChI Key ZTCKUVQHKIMCLI-UHFFFAOYSA-N
Solubility good in most organic solvents
Appearance colorless/yellowish oil
Boiling Point 763.6±60.0°C (Predicted)
  • Product Specification
Storage Store at -20°C

Computed Properties

XLogP3 5.3
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 12
Rotatable Bond Count 31
Exact Mass 784.40638314 g/mol
Monoisotopic Mass 784.40638314 g/mol
Topological Polar Surface Area 119Ų
Heavy Atom Count 55
Formal Charge 0
Complexity 949
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Patents

Publication NumberTitlePriority Date
US-10308943-B2 Compositions with improved intravitreal half-life and uses thereof 2016-02-08
US-2018127754-A1 Bivalent antisense oligonucleotides 2010-03-24
US-5674856-A Modified oligodeoxyribonucleoditides 1993-01-29
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