Cyanine5.5 amine

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Cyanine5.5 amine

Cyanine5.5 amine | 2097714-45-7

Catalog Number F02-0010
Category Cyanine5.5
Molecular Formula C46H58Cl2N4O
Molecular Weight 753.88
Catalog Number Size Price Quantity
F02-0010 -- $--

Product Introduction

Cyanine5.5 (Cy5.5® analog) amine derivative. The dye contains a free amine group which can be conjugated with a variety of functionalities, including NHS esters, and epoxides.Cyanine5.5 is a far red dye which works fine for live organism imaging, and applications requiring low fluorescence background.

Chemical Information

Related CAS 2097714-44-6 (without anion)
Purity NMR 1H, HPLC-MS (95%)
IUPAC Name N-(6-aminohexyl)-6-[(2E)-1,1-dimethyl-2-[(2E,4E)-5-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)penta-2,4-dienylidene]benzo[e]indol-3-yl]hexanamide;chloride;hydrochloride
Canonical SMILES CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)C)C=CC=CC=C4C(C5=C(N4CCCCCC(=O)NCCCCCCN)C=CC6=CC=CC=C65)(C)C)C.Cl.[Cl-]
InChI InChI=1S/C46H56N4O.2ClH/c1-45(2)40(49(5)38-29-27-34-20-13-15-22-36(34)43(38)45)24-10-8-11-25-41-46(3,4)44-37-23-16-14-21-35(37)28-30-39(44)50(41)33-19-9-12-26-42(51)48-32-18-7-6-17-31-47;;/h8,10-11,13-16,20-25,27-30H,6-7,9,12,17-19,26,31-33,47H2,1-5H3;2*1H
InChI Key KVJPEAWDFIBHDL-UHFFFAOYSA-N
Solubility practically insoluble in water (< 2 uM), good in polar organic solvents (DMF, DMSO, alcohols)
Appearance dark blue powder
  • Product Specification
  • Application
ε, L⋅mol-1⋅cm-1 198000
Fluorescence Quantum Yield 0.2
Excitation 684
Emission 710
Storage 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

Cyanine5.5 amine, a potent fluorescent dye highly valued for its exceptional photostability and brightness, finds extensive utility in various biotechnological and medical domains. Here are four key applications of Cyanine5.5 amine:

Fluorescence Imaging: An indispensable tool in fluorescence imaging techniques, Cyanine5.5 amine serves to label proteins, nucleic acids, and diverse biomolecules, enabling researchers to peer into the intricate structures and dynamic processes within cells with unparalleled specificity and sensitivity. The dye’s near-infrared emission emerges as a game-changer, particularly beneficial for conducting deep tissue imaging within living organisms, unraveling hitherto unseen cellular phenomena.

Flow Cytometry: In the realm of flow cytometry, Cyanine5.5 amine takes center stage as it acts as a beacon, marking specific cell surface markers that facilitate the sorting and analysis of heterogeneous cell populations with precision and finesse. This application assumes pivotal importance in fields ranging from immunophenotyping to cancer diagnostics and stem cell research, leveraging the fluorescent properties of Cyanine5.5 amine to conduct multi-parametric analyses in tandem with other fluorochromes, opening new avenues in cellular exploration.

Fluorescence In Situ Hybridization (FISH): A cornerstone of genetic investigation, Cyanine5.5 amine emerges as a potent ally when tethered to probes utilized in fluorescence in situ hybridization, a technique pivotal for pinpointing and localizing specific DNA or RNA sequences within cells. This application finds wide-ranging utility in genetic mapping, chromosomal aberration studies, and the diagnosis of genetic disorders, with the high signal-to-noise ratio of Cyanine5.5 amine enhancing the precision and reliability of these genetic explorations.

Optical Probes for in Vivo Imaging: Harnessing the power of Cyanine5.5 amine, researchers delve into the development of optical probes tailored for in vivo imaging studies, unveiling new vistas in disease monitoring and treatment assessment. These probes, armed with the ability to target specific tissues or disease markers, pave the way for non-invasive tracking of disease progression and treatment efficacy. The near-infrared fluorescence properties of Cyanine5.5 amine ensure deep tissue penetration and minimal interference from biological tissue autofluorescence, marking a paradigm shift in the realm of in vivo imaging technologies.

Computed Properties

Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 15
Exact Mass 752.3987679 g/mol
Monoisotopic Mass 752.3987679 g/mol
Topological Polar Surface Area 61.4Ų
Heavy Atom Count 53
Formal Charge 0
Complexity 1290
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 3
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 3
Compound Is Canonicalized Yes
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