BAPTA

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BAPTA

BAPTA | 85233-19-8

Catalog Number A14-0130
Category Calcium, Chloride Indictors and Other indicators
Molecular Formula C22H24N2N2O10
Molecular Weight 476.438
Catalog Number Size Price Quantity
A14-0130 -- $--

Product Introduction

BAPTA is a useful precusor to calcium indicator synthesis.

Chemical Information

Synonyms 1,2-Bis(2-Aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)glycine
IUPAC Name 2-[2-[2-[2-[bis(carboxymethyl)amino]phenoxy]ethoxy]-N-(carboxymethyl)anilino]acetic acid
Canonical SMILES C1=CC=C(C(=C1)N(CC(=O)O)CC(=O)O)OCCOC2=CC=CC=C2N(CC(=O)O)CC(=O)O
InChI InChI=1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)
InChI Key FTEDXVNDVHYDQW-UHFFFAOYSA-N
Appearance Solid Powder
  • Product Specification
  • Application
Signal Warning
GHS Hazard Statements H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

BAPTA, a versatile chemical compound widely utilized in biological research, is renowned for its exceptional ability to effectively chelate calcium ions, thereby buffering intracellular calcium levels. Here are four key applications of BAPTA:

Calcium Signaling Studies: Delving into the intricate world of calcium signaling pathways across diverse cell types, researchers heavily rely on BAPTA to unravel the mysteries of cellular communication. By binding with free calcium ions, BAPTA meticulously maintains precise calcium concentrations, offering a controlled environment for scrutinizing the timing and specificity of calcium-dependent events. This fundamental research sheds light on how calcium signals intricately regulate vital cellular functions like muscle contraction, neurotransmission, and cell growth.

Neurophysiological Research: In the realm of neurophysiological exploration, BAPTA emerges as a critical tool for dissecting the role of calcium in neuronal signaling and synaptic plasticity. Researchers harness the power of BAPTA to buffer transient calcium fluctuations during experiments involving neurons and brain slices, providing invaluable insights into the mechanisms underpinning learning, memory, and other neurological processes modulated by dynamic calcium dynamics.

Tissue Engineering: Pioneering advancements in tissue engineering, BAPTA serves as a keystone in controlling calcium-dependent processes governing cell adhesion and differentiation. Through precise regulation of calcium levels using BAPTA, scientists can fine-tune the conditions conducive to cultivating tissues and organs in vitro.

Cancer Research: Unveiling the enigmatic realm of cancer biology, BAPTA emerges as a valuable ally in deciphering the intricate role of calcium signaling in cell proliferation, apoptosis, and metastasis. Researchers leverage BAPTA to disrupt calcium-dependent pathways within cancer cells, unraveling the repercussions of such perturbations.

Computed Properties

XLogP3 2.2
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 12
Rotatable Bond Count 15
Exact Mass 476.14309497 g/mol
Monoisotopic Mass 476.14309497 g/mol
Topological Polar Surface Area 174Ų
Heavy Atom Count 34
Formal Charge 0
Complexity 613
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Literatures

PMIDPublication DateTitleJournal
36731763 2023-03-01 Cadmium induced mouse spermatogonia apoptosis via mitochondrial calcium overload mediated by IP3R-MCU signal pathway Toxicology
36308466 2023-01-31 NLRP3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice Toxicological sciences : an official journal of the Society of Toxicology
31969611 2020-01-22 Rotenone-induced inner retinal degeneration via presynaptic activation of voltage-dependent sodium and L-type calcium channels in rats Scientific reports
29111403 2018-01-15 The critical role of autophagy in cadmium-induced immunosuppression regulated by endoplasmic reticulum stress-mediated calpain activation in RAW264.7 mouse monocytes Toxicology
28836330 2017-12-01 Actein alleviates 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated cellular dysfunction in osteoblastic MC3T3-E1 cells Environmental toxicology

Patents

Publication NumberTitlePriority Date
CN-114748682-A Composition for preparing burn wound dressing and preparation and preparation method thereof 2022-04-26
CN-114748683-A Composition for preparing burn wound dressing and preparation and preparation method thereof 2022-04-26
CN-114831967-A Broad-spectrum antioxidant silk fibroin band-aid and its preparation and application 2022-04-26
CN-114832144-A Broad-spectrum antibacterial and antioxidant silk fibroin band-aid and its preparation and application 2022-04-26
CN-113827607-A Application of ouabain in preparation of preparations for down-regulating PD-L1 level in tumor cells 2021-09-03
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