2',7'-Dichlorofluorescein

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2',7'-Dichlorofluorescein

2',7'-Dichlorofluorescein | 76-54-0

Catalog Number A17-0109
Category Fluorescein FAM
Molecular Formula C20H10Cl2O5
Molecular Weight 401.20
Catalog Number Size Price Quantity
A17-0109 -- $--

Product Introduction

2',7'-Dichlorofluorescein can be used in the synthesis of 2',7'-Dichlorodihydrofluorescein, which is a cell-permeable non-fluorescent probe.

Chemical Information

Synonyms 2',7'-dichloro-3',6'-dihydroxy-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one; 2',7'-Dichlorofluorescein; Fluorescein 27; Fluorescein 548
IUPAC Name 2',7'-dichloro-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
Canonical SMILES C1=CC=C2C(=C1)C(=O)OC23C4=CC(=C(C=C4OC5=CC(=C(C=C35)Cl)O)O)Cl
InChI InChI=1S/C20H10Cl2O5/c21-13-5-11-17(7-15(13)23)26-18-8-16(24)14(22)6-12(18)20(11)10-4-2-1-3-9(10)19(25)27-20/h1-8,23-24H
InChI Key VFNKZQNIXUFLBC-UHFFFAOYSA-N
  • Product Specification
Signal Warning
GHS Hazard Statements H315 (90.91%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Computed Properties

XLogP3 4.7
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 0
Exact Mass 399.9905288 g/mol
Monoisotopic Mass 399.9905288 g/mol
Topological Polar Surface Area 76Ų
Heavy Atom Count 27
Formal Charge 0
Complexity 585
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Literatures

PMIDPublication DateTitleJournal
34958783 2022-01-15 Effect of major components of Tripterygium wilfordii Hook. f on the uptake function of organic anion transporting polypeptide 1B1 Toxicology and applied pharmacology
22910297 2012-11-01 Oxidative effects of nanosecond pulsed electric field exposure in cells and cell-free media Archives of biochemistry and biophysics
22939937 2012-11-01 Proinflammatory activation of macrophages by bisphenol A-glycidyl-methacrylate involved NFκB activation via PI3K/Akt pathway Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
22940460 2012-11-01 Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes Toxicology and applied pharmacology
23022691 2012-11-01 Nuclear targeting terpyridine iron(II) complexes for cellular imaging and remarkable photocytotoxicity Journal of inorganic biochemistry

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